Program

Vega Hall
Tokushima, Japan February 27- March 1, 2007

Welcome to Glycobiology and Sphingobiology 2007
- Hakomori Commemorative Forum -

With special recognition of pioneering achievements and significant advancement of the fields of membrane glycobiology and sphingobiology by Sen-itiroh Hakomori

Venue: Vega Hall, Otsuka Pharmaceutical Company, Tokushima, Japan

Program

February 27, 2007

13:00 - 15:00	Registration
15:30 - 15:45	Opening remarks:	Roger A..Laine
15:45 - 16:00	Introduction	Yasuyuki Igarashi
16:00 - 17:30	Plenary Lecture	Chair: Max Burger
	Sen-itiroh Hakomori "Traveling for the Glyco - and Sphingobiology Path"
18:00 - 19:30	Welcome Reception

February 28, 2007

	Session 1:	Mechanisms and Effects of Alteration of Carbohydrate Determinants in Cancers

	Chair:	Akira Kobata and Henrik Clausen

S-1-1		Reiji Kannagi
9:00 - 9:20		Dr. Hakomori's concepts revisited: Current relevance of 'incomplete synthesis' and 'neo-synthesis' for cancer-associated alteration of carbohydrate determinants

S-1-2		Taeko Dohi
9:20 - 9:40		'Incomplete synthesis' of Sd(a) carbohydrate determinants in gastrointestinal cancer

S-1-3		Henrik Clausen
9:40 - 10:00		Twenty-Plus years in the footpath of Sen's tumor-associated carbohydrate antigens - Cancer-specific Tn/STn-glycopeptide epitopes

S-1-4		Taeko Miyagi
10:00 - 10:20		Role of ganglioside sialidase in human cancers

S-1-5(P-17)		Koichi Furukawa
10:20 - 10:30		Involvement of Integrins in the Malignant Phenotypes Enhanced by Ganglioside GD3 Expression in Human Melanoma Cells



Coffee Break

	Session 2:	Carbohydrate markers for Benign and Malignant Diseases

	Chair:	Tatsuro Irimura and Kunihiko Suzuki

S-2-1		John Magnani
10:55 - 11:15		Sialyl Le^a and sialyl Le^x from discovery to drug development

S-2-2		Seiichi Saito
11:15 - 11:35		RM2 antigen (β1,4-GalNAc-disialyl Lc4) as a new marker for prostate cancer

S-2-3		Gustavo Nores
11:35 - 11:55		The immune response to self-glycans: Autoimmunity and cancer therapy

S-2-4(P-49)		Jacques Portoukalian
11:55 - 12:05		Suppression of GD3 synthase gene expression in human melanoma cells blocks the ability of the cells to induce neoangiogenesis upon xenografting in nude mice

S-2-5(P-50)		Tamao Endo
12:05 - 12:15		Combined approaches to diagnosis congenital muscular dystrophies with α-dystroglycan hypoglycosylation

S-2-6(P-69)		Kazuyuki Sugahara
12:15 - 12:25		Functions of chondroitin sulfate/dermatan sulfate chains in brain development: Critical roles of E and iE disaccharide units recognized by a single chain antibody GD3G7



Lunch and Poster Presentation

	Session 3:	Carbohydrate-Carbohydrate Interactions

	Chair:	Max Burger and Nicole Bauman

S-3-1		Soledad Penades
14:00 - 14:20		Understanding carbohydrate-carbohydrate interaction by means of glyconanotechnology

S-3-2		Kazukiyo Kobayashi
14:20 - 14:40		Analysis of GM3-Gg3 carbohydrate-carbohydrate interaction by surface pressure area isotherm and surface plasmon resonance

S-3-3		Susumu Kusunoki
14:40 - 15:00		Antibodies against ganglioside complexes in Guillian Barre syndrome: New aspect of research

S-3-4		Motonori Hoshi
15:00 - 15:20		Glycosignals for fertilization

S-3-5(P-3)		Koichi Kato
15:20 - 15:30		920 MHz Ultra-high field NMR analyses of sugar-protein interact



Coffee Break

	Session 4:	Pharmaceutical Applications: Carbohydrates;

	Chair:	Roger A. Laine and Naoyuki Taniguchi

S-4-1		Nobuo Hanai
15:55 - 16:15		The therapeutic application of humanized antibodies with carbohydrate modification and potent immune effector function

S-4-2		Clifford Lingwood
16:15 - 16:35		Soluble glycosphingolipids mimics as therapeutics for disease

S-4-3		Steven B. Levery
16:35 - 16:55		Glycosphingolipidmics of pathogenic and model fungi: Structure, biosynthesis, potential applications to therapeutic and diagnostic strategies for fungal disease

S-4-4		Helio Takahashi
16:55 - 17:15		Role of glycosylation in parasites

S-4-5		Takao Taki
17:15 - 17:35		Ganglioside-replica peptides selected from a phage-peptide library induce a ganglioside antibody response

17:35 - 18:30		Poster Presentation

March 1, 2007

	Session 5:	Glycosynapse and Cell-Cell Interactions

	Chair:	Akemi Suzuki and Y. T. Li

S-5-1		Adriane Todeschini
9:00 - 9:20		Inhibition of integrin-dependent Met kinase activity by GM2/tetraspanin CD82 complex in glycosynaptic microdomain

S-5-2		Yutaka Miura
9:20 - 9:40		Glycosynapse-1-gangliosides and oncogenic phenotypes

S-5-3		Joan Boggs
9:40 - 10:00		The glycosynapse in the myelin sheath

S-5-4		Eric G. Bremer
10:00 - 10:20		Functional significance of direct interaction between gangliosides and growth factor receptors

S-5-5(P-72)		Motoko Takahashi
10:20 - 10:35		The Asn⁴¹⁸-linked N-glycan of ErbB3 plays a crucial role in preventing spontaneous heterodimerization and tumor promotion



Coffee Break

	Session 6:	Integrins and Other Cell-Cell Interactions

	Chair:	Carl Gahmberg and Yasuo Suzuki

S-6-1		Kiyotoshi Sekiguchi
11:00 - 11:20		Molecular basis of adhesive interactions of cells with the basement membrane

S-6-2		Carl Gahmberg
11:20 - 11:40		From fibronectin to molecular studies of leukocyte adhesion

S-6-3		William Carter
11:40 - 12:00		Function of GP140/CDCP1 in Adhesion of Epithelium

S-6-4		Tsutomu Tsuji
12:00 - 12:20		Regulation of alpha3 integrin expression in cancer cells and its role in peritoneal metastasis

S-6-5(P-9)		Honke Koichi
12:20 - 12:30		Oligodendrocyte development in cerebroside sulfotransferase-null mice:A role for the sulfoglycolipid, sulfatide in oligodendrocytes and CNS myelin



Lunch and Poster Presentation

	Session 7:	Membrane Microdomain Function

	Chair:	Yoshitaka Nagai and Konrad Sandhoff

S-7-1		Kazuhisa Iwabuchi
14:00 - 14:20		Significance of fatty acid chain length of lactosylceramide on the lipid domain-mediated signal transduction in neutrophils

S-7-2		Pablo S. Aguilar
14:20 - 14:40		Cellular organization of eisosomes on yeast’s plasma membrane

S-7-3		Konrad Sandhoff
14:40 - 15:00		Interpretation of components found in microdomain isolation

S-7-4		Toshihide Kobayashi
15:00 - 15:20		Chaos rather than rafts

S-7-5		Yoshio Hirabayashi
15:20 - 15:40		Phosphatidylglucoside as a new marker of developing radial glia cells

S-7-6(P-36)		Yoshifumi Jigami
15:40 - 15:50		GPI-Anchored proteins and membrane lipid microdomain in yeast

S-7-5(P-31)		Naoya Kojima
15:50 - 16:00		Functional counter receptors for E-selectin on Colo 201 cell Surface are localized in membrane microdomain and closely associated with non-receptor type tyrosine kinase


Coffee Break

	Session 8:	Pharmaceuticals and Sphingoids

	Chair:	Guido Tettamanti and Yasuyuki Igarashi

S-8-1		Alessandro Prinetti
16:25 - 16:45		Altered sphingolipid metabolism and membrane organization are associated with reduced invasivity in HPR-resistant human ovarian carcinoma cells

S-8-2		David Lefer
16:45 - 17:05		Sphingolipid therapy in the setting of ischemia-reperfusion injury

S-8-3		Gabor Tigyi
17:05 - 17:30		Rational drug design for sphingosine-1-phosphate receptors

S-8-4		Yutaka Yatomi
17:30 - 17:40		Importance of sphingosine-1-phosphate in vascular biology: its application to laboratory medicine

17:40 - 17:50		Closing Remarks Yoshitaka Nagai

19:00 - 21:00		Dinner